diff --git a/src/index.js b/src/index.js
index 17ca86f..07f149f 100644
--- a/src/index.js
+++ b/src/index.js
@@ -175,6 +175,11 @@ async function handleRequest(request, env, ctx) {
 
                 // Check if this is a Hugging Face API request
                 const isHF = isHuggingFaceAPIRequest(request, url);
+                const shouldVaryCacheByOrigin =
+                  platform === 'flathub' && isFlatpakReferenceFilePath(effectivePath);
+                const cacheTargetUrl = shouldVaryCacheByOrigin
+                  ? `${targetUrl}${targetUrl.includes('?') ? '&' : '?'}__xget_origin=${encodeURIComponent(url.origin)}`
+                  : targetUrl;
                 const canUseCache = request.method === 'GET' || request.method === 'HEAD';
                 const shouldPassthroughRequest =
                   isGit || isGitLFS || isDocker || isAI || isHF || !canUseCache;
@@ -199,7 +204,7 @@ async function handleRequest(request, env, ctx) {
                 ) {
                   try {
                     // For Range requests, try cache match first
-                    const cacheKey = new Request(targetUrl, {
+                    const cacheKey = new Request(cacheTargetUrl, {
                       method: 'GET',
                       headers: request.headers
                     });
@@ -211,7 +216,7 @@ async function handleRequest(request, env, ctx) {
                       // If Range request missed cache, try with original request to see if we have full content cached
                       const rangeHeader = request.headers.get('Range');
                       if (rangeHeader) {
-                        const fullContentKey = new Request(targetUrl, {
+                        const fullContentKey = new Request(cacheTargetUrl, {
                           method: 'GET', // Always use GET method for cache key consistency
                           headers: new Headers(
                             [...request.headers.entries()].filter(
@@ -631,7 +636,7 @@ async function handleRequest(request, env, ctx) {
                     ) {
                       const rangeHeader = request.headers.get('Range');
                       const cacheKey = rangeHeader
-                        ? new Request(targetUrl, {
+                        ? new Request(cacheTargetUrl, {
                             method: 'GET',
                             headers: new Headers(
                               [...request.headers.entries()].filter(
@@ -639,7 +644,7 @@ async function handleRequest(request, env, ctx) {
                               )
                             )
                           })
-                        : new Request(targetUrl, { method: 'GET' });
+                        : new Request(cacheTargetUrl, { method: 'GET' });
 
                       try {
                         if (ctx && typeof ctx.waitUntil === 'function') {
@@ -652,7 +657,7 @@ async function handleRequest(request, env, ctx) {
 
                         if (rangeHeader && response.status === 200) {
                           const rangedResponse = await cache.match(
-                            new Request(targetUrl, {
+                            new Request(cacheTargetUrl, {
                               method: 'GET',
                               headers: request.headers
                             })
diff --git a/test/unit/flathub-rewrite.test.js b/test/unit/flathub-rewrite.test.js
index b6b4070..71e9b19 100644
--- a/test/unit/flathub-rewrite.test.js
+++ b/test/unit/flathub-rewrite.test.js
@@ -94,6 +94,42 @@ describe('Flathub Response Rewriting', () => {
     expect(body).toContain('RuntimeRepo=https://example.com/flathub/repo/flathub.flatpakrepo');
   });
 
+  it('uses host-scoped cache keys for rewritten Flathub descriptors', async () => {
+    const cacheEntries = new Map();
+
+    vi.stubGlobal('caches', {
+      default: {
+        match: vi.fn(async request => cacheEntries.get(request.url) || null),
+        put: vi.fn(async (request, response) => {
+          cacheEntries.set(request.url, response.clone());
+        })
+      }
+    });
+
+    const fetchSpy = vi.spyOn(globalThis, 'fetch').mockImplementation(
+      async () =>
+        new Response(`[Flatpak Repo]\nUrl=https://dl.flathub.org/repo/`, {
+          status: 200,
+          headers: { 'Content-Type': 'application/octet-stream' }
+        })
+    );
+
+    const responseA = await worker.fetch(
+      new Request('https://mirror-a.example/flathub/repo/flathub.flatpakrepo'),
+      {},
+      executionContext
+    );
+    const responseB = await worker.fetch(
+      new Request('https://mirror-b.example/flathub/repo/flathub.flatpakrepo'),
+      {},
+      executionContext
+    );
+
+    expect(fetchSpy).toHaveBeenCalledTimes(2);
+    expect(await readUtf8Text(responseA)).toContain('Url=https://mirror-a.example/flathub/repo/');
+    expect(await readUtf8Text(responseB)).toContain('Url=https://mirror-b.example/flathub/repo/');
+  });
+
   it('does not rewrite binary repository metadata like summary files', async () => {
     vi.spyOn(globalThis, 'fetch').mockResolvedValue(
       new Response('summary-binary-payload', {